Do Nootropics Cause Depression? The Facts You Need to Know

Do Nootropics Cause Depression? The Facts You Need to Know - Lucid™

Nootropics have gained significant popularity in recent years for their potential to boost cognitive function and enhance mental clarity. Many even use nootropics to support mental health–so it seems a little counterintuitive to claim that nootropics may cause some of the very issues we’re trying to solve.

Nonetheless, a question that often arises is–can nootropics cause depression?

In this article, we'll explore the connection between nootropics and depression and provide you with the essential facts you need to make an informed decision about their use and their potential impact on your mental health.

Let’s go:

Key Takeaways

  • Nootropics do not directly cause depression, but individual reactions may vary.
  • Factors such as the type of nootropic and individual vulnerabilities play a significant role.
  • Mindful use, recommended dosages, and product quality are crucial for a positive experience.

What Are Nootropics?

Before delving into the potential link between nootropics and depression, let's first understand what nootropics are. 

Nootropics, often referred to as "smart drugs" or "cognitive enhancers," are substances that individuals use to enhance their cognitive abilities, including memory, focus, and creativity. These can range from prescription drugs to natural supplements and even nootropic food sources.

They do so by interacting with the brain in a way that regulates the production of certain neurotransmitters. For instance, some nootropics may help to upregulate GABA or dopamine, two neurotransmitters required for good focus and attention.

However, because nootropics impact the balance of crucial neurotransmitters, like serotonin, dopamine, norepinephrine, and more, they can also have an impact on your mental health. Thus, many people reach for nootropics to help manage depression, anxiety, ADHD, and a wide range of other mood or cognition-related issues.

So, onto the golden question–does it go both ways? Can nootropics actually cause depression?

Exploring The Link Between Nootropics and Depression

The concern about nootropics causing depression is valid–these substances do influence the same neurotransmitters and brain functions implicated in depression. Some people fear that altering the delicate balance of chemicals in the brain may lead to mood disorders, including depression.

What does research say about nootropics and depression?

Extensive research on the connection between nootropics and depression is still ongoing. While there is no conclusive evidence suggesting that nootropics directly cause depression, it's essential to consider individual factors and the type of nootropic being used. Different nootropic substances may have a different impact on mental health and therefore some may be more likely to cause depression than others.

Considering Individual Factors

Depression is a complex condition influenced by various genetic, environmental, and lifestyle factors. Not everyone who takes nootropics will experience depressive symptoms, and those who do may have pre-existing vulnerabilities.

Some individual factors to consider include:

  • Genetic Predisposition: Some individuals may be genetically more susceptible to the potential negative effects of specific nootropics on mental health. Genetic variations can alter how the brain responds to these substances, making certain individuals more susceptible to developing depression or other mental health issues.
  • Underlying Mental Health Conditions: Individuals with pre-existing mental health conditions, such as anxiety or depression, may be more vulnerable to the negative effects of specific nootropics. These substances can interact with neurotransmitters and brain chemicals, potentially worsening symptoms or causing new ones to emerge.
  • Dosage: The dosage of nootropics can significantly impact their effects on the mental health of healthy individuals. Consuming doses higher than recommended or exceeding safe limits increases the risk of adverse effects, including depression. It's essential to adhere to recommended dosages and consult with a healthcare professional if in doubt.
  • Duration of Use: The duration of nootropic use can also affect mental health. Prolonged use, particularly without breaks or periods of rest, can potentially disrupt brain chemistry and contribute to mood disturbances and depression.

It's critical to understand that the impact of nootropics on mental health varies widely and is highly individualized.

Different Nootropics and Their Impact on Mental Health

Different nootropics work in various ways and have different effects on the brain. Some may enhance mood and alleviate symptoms of depression, while others might have the opposite effect.

To gain a clearer understanding, let's look at some of the common nootropics and their potential effects on depression. We’ll divide this into two sections–natural nootropics and synthetic nootropics supplements.

Natural Nootropics


Caffeine is the most well known natural nootropic in the world, and it has undeniable benefits for boosting energy and focus. It works by blocking the production of adenosine which can help you feel less tired and more alert.

Depression link:

There is no proven link between caffeine consumption in increased depression symptoms, but some experts believe that excessive caffeine intake could worsen existing depression by suppressing dopamine production.


L-Theanine is an amino acid that's found in most kinds of tea leaves and is known for its relaxing effects that are soothing without making you drowsy. According to research, taking L-theanine with caffeine may reduce caffeine’s impact on your blood pressure or anxiety levels.

Plus, the two compounds synergize like no other. According to research, a combination of L-theanine and caffeine has been associated with improved reaction times, improved word recognition, and improved attention, improved ability to switch between tasks more easily, and higher accuracy upon completing tasks.

Depression link:

There is no link between L-theanine and worsening depression. In fact, some experts theorize that L-theanine could help remedy some symptoms of depression due to its potential benefits for calming anxiety. Limited evidence supports the use of daily L-theanine supplements for depression.


Omega-3 fatty acids (which can be divided into two main categories–DHA and EPA) are necessary for most brain function. Omega-3 is known to help improve many facets of cognitive function, from increasing focus to decreasing anxiety and depression. A lack of omega-3 is associated with cognitive dysfunctions.

One study concluded that people with low Omega-3 levels had lower brain volume and scored lower on tests involving visual memory and executive function, like tasks involving problem solving, multi-tasking, and abstract thinking.

Another study looked at the impact of a fish oil diet (or a diet containing plenty of omega-3) on fruit flies’ ability to learn. In this study, fruit flies fed the fish oil had a positive impact on learning and memory compared to fruit flies fed a standard diet.

Depression link:

There is no link between omega-3 and worsening depression. In fact, it is often thought to promote a favorable mood and decrease depression risk.

Ginkgo Biloba

Ginkgo Biloba is one of the oldest nootropic supplements we have and it comes from one of the world's oldest trees–the Ginkgo tree. Researchers believe that ginkgo’s ability to improve blood flow in the body. In animal animal models and test-tube models, it’s been shown to help promote the growth of neurons.

Depression link:

Although one case report suggests that Ginkgo causes mood dysregulation in a patient with schizophrenia, there is currently no evidence linking ginkgo to depression in healthy adults. 

In fact, various studies have found that ginkgo may help to reduce symptoms of depression, especially when paired with an antidepressant. One study found that post-stroke patients with depression had a better experience when taking their antidepressants with ginkgo as opposed to taking their antidepressants alone.


Alpha-GPC helps to increase acetylcholine, a neurotransmitter that helps facilitate learning and memory. One study suggests that alpha-GPC may have a wider range of cognitive benefits pertaining to four primary areas of cognition–verbal memory, visual memory, verbal learning, and executive function. Plus, it’s been found to increase mental performance speed when paired with caffeine as opposed to taking caffeine alone.

Depression link:

There is no known link between alpha-GPC and worsening depression, but it is known that elevated brain choline levels may be linked to depression. However, elevated choline levels are generally only caused by long-term overuse and not proper use of alpha-GPC.

Lion’s Mane

Lion’s mane mushroom is chock full of polysaccharides that help support a healthy gut microbiome–a colony of good bacteria that experts now know plays a role in most aspects of both mental and physical health.

Most notably, though, Lion’s Mane is thought to stimulate neurogenesis, the growth of new nerve cells. According to the research we have, though, lion’s mane is thought to improve memory, focus, and mental endurance, and may be in the running for new medications designed to treat dementia.

Depression link:

There is no known link between lion’s mane and worsening depression. In fact, lion’s mane has been found to improve depression symptoms in both animal and human studies. 


Cordyceps is a more popular functional mushroom with an age-old reputation. Cordyceps is most often linked to increased endurance, though research has also found it to have possible benefits for improving memory and learning in animal models thanks to extraordinary antioxidant properties.

Depression link:

There is no link between cordyceps and worsening depression. Research indicates that some versions of cordyceps may have antidepressant properties.

Rhodiola Rosea

Rhodiola is another age-old remedy that’s chock full of active medicinals–including rosavin and salidroside, two compounds known to be potent adaptogens. Adaptogens are compounds that help the body respond to stress.

One review of 36 animal studies stated that “R. rosea L. can improve learning and memory function” possibly due its “antioxidant properties, cholinergic regulation, anti-apoptosis activities, anti-inflammatory, improving coronary blood flow, and cerebral metabolism.”

Thanks to its adaptogenic effects, taking it daily has been linked to reduced mental fatigue and increased feelings of well-being while under stress.

Depression link:

There is no link between rhodiola rosea and depression, though some possible side effects (though rare and mild) may include agitation, insomnia, anxiety, and headaches.


Curcumin is the yellow substance that gives turmeric its brilliant color–and it’s well known for its potential anti-inflammatory effects. You may not know, however, that it’s been shown to have a positive impact on serotonin and dopamine levels, and has been highlighted as a potential treatment for depression and related disorders.

Other research has linked curcumin to total body benefits, like prevention against cancer, arthritis, and heart disease.

Depression link:

There is no known link between curcumin and worsening depression.

Bacopa Monnieri

Bacopa monnieri is another ancient remedy that has been linked to improved processing speed and reduced reaction times, as well as memory enhancement and the prevention of age-related cognitive decline. Researchers believe that it has powerful antioxidant properties that can help prevent oxidative stress, a primary cause of neurodegeneration as we age.

Depression link:

There is no known link between bacopa monnieri and worsening depression. In fact, limited evidence suggests that it may help to improve depression and anxiety symptoms.

One study found that taking 300 milligrams of bacopa monnieri daily for 12 weeks significantly reduced depression and anxiety scores in adults compared to a placebo. Another study found that taking 500 milligrams of bacopa monnieri twice daily for 4 weeks reduced depression, anxiety, and stress levels.

Panax Ginseng

Ginseng is easy to find on nutrition labels for energy drinks and brain-boosting supplements–and for a good reason. It’s often linked to reduced mental fatigue and improved cognitive performance, especially when doing difficult tasks.

Like other nootropics on this list, it may not act directly on any neurotransmitter pathway, rather it may increase blood flow to the brain. Others believe that many of its benefits may have to do with its anti-inflammatory effects, which may help to reduce oxidative stress.

Depression Link:

There is no known link between panax ginseng and worsening depression. In fact, it has been shown to exert antidepressant properties by inhibiting interaction within the HPA axis in animal trials. Several studies suggest that it may have an underlying role in preventing and managing depressive disorders.

Synthetic Nootropics


Racetams, such as piracetam, are a class of synthetic nootropics known for their memory-enhancing properties. Their influence on mood is less clear, and individual reactions vary. Racetams are generally available without a prescription.

Depression link:

Although racetams like piracetam have been associated with a wide range of benefits, many people report feeling irritable or experiencing mood swings after starting piracetam. Other reported side effects of piracetam include weight gain, weakness, increased libido, hypersexuality and increased risk of clinical depression.


Prescription nootropics like Modafinil can improve wakefulness and alertness. These stimulant drugs are often used to treat sleep disorders, like narcolepsy. However, they are not recommended for individuals with a history of mood disorders, as they may exacerbate symptoms of depression.

Depression link:

Although Modafinil has been successfully used alongside an antidepressant to manage psychiatric disorders, it has also been linked to worsened depression symptoms and even symptoms of psychosis in patients with bipolar disorder.


Noopept is another synthetic nootropic that is touted for its cognitive-enhancing abilities. Like racetams, it can affect memory and learning, but its impact on mood remains uncertain.

Depression link:

While research on the depression-related effects of Noopept is limited, some users have reported experiencing mood swings and irritability after taking it. Individual responses may vary.

Avoiding Side Effects: The Importance of Dosage and Quality

When considering the potential link between nootropics and depression, it's crucial to pay attention to dosage and product quality. Low-quality or excessive use of nootropics can lead to adverse effects, including changes in mood and increased risk of depression.

Dosage Matters

The adage "the dose makes the poison" holds true for nootropics. Using these substances within recommended guidelines is essential to minimize the risk of negative effects on mood and mental health.

Quality Assurance

Choosing reputable suppliers and ensuring the purity of the nootropic you're consuming can significantly impact your overall experience. Lower-quality products may contain impurities that could negatively affect your mood. If buying products over the counter, look for products that are naturally sourced and third-party tested for impurities and label accuracy.

Your Brain, Your Responsibility

In the quest for enhanced cognitive performance, remember that your brain is unique. What works for one person may not work for another. It's essential to consult a healthcare professional before starting any new nootropic regimen, especially if you have a history of depression or other mental health conditions.

Summing It Up

In conclusion, the link between nootropics and depression is a complex and evolving topic. While there is no definitive proof that nootropics directly cause depression, individual reactions may vary.

In general, it seems like many natural nootropics, when used responsibly, are less likely to have a negative impact on mental health than synthetic nootropics. However, synthetic nootropics, especially when prescribed by a doctor, are sometimes the best option to treat more severe symptoms, such as memory loss or symptoms of ADHD. To ensure a positive experience, consider the following:

  • Be mindful of your nootropic choices and their potential effects on mood.
  • Stick to recommended dosages to avoid negative side effects.
  • Choose high-quality products from reputable sources.
  • Consult with a healthcare professional if you have a history of depression or other mental health conditions.

Remember that the decision to use nootropics should be an informed one. Pay attention to your body's signals and make choices that support your overall well-being and mental health.

Lucid beverages contain a blend of brain-boosting nootropics + powerful mushrooms designed to unlock your brain's full potential so you can zone in on what's important. 

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