Maitake Mushroom Side Effects: Understanding the Risks and Benefits

Maitake Mushroom Side Effects: Understanding the Risks and Benefits - Lucid™

Maitake mushroom is a species of edible mushroom known for its fan-like appearance and unique taste. It has been revered for its potential health benefits and culinary uses in traditional Eastern medicine for centuries. More recently, maitake mushrooms have gained popularity in the Western world as well, especially as a dietary supplement or alternative medicine.

Medicinal mushrooms are generally considered to be safe and well-tolerated by most individuals. Still, like any other supplement or natural remedy, there may be some potential maitake mushroom side effects to look out for. 

Before you dive into a maitake mushroom wellness regimen with both feet, let’s take a look at potential side effects, drug interactions, and other safety risks:

Key Takeaways

Maitake may offer a wide range of benefits, both for nutritional and therapeutic purposes.

Like all supplements, lack of quality control poses a serious risk for consumers.

Other maitake side effects may include upset stomach, allergic reaction, or adverse interactions with medications.

What is Maitake and What are Its Benefits?

Before delving into the side effects, let's first understand the sentiment behind using maitake as a wellness supplement. 

Maitake is used both as a nutritional and therapeutic supplement, and different forms of maitake mushroom may have different benefits. Subsequently, different forms of maitake may also have different drawbacks and potential side effects. 

Maitake Nutritional Profile

Maitake mushrooms are low in calories and fat but rich in essential vitamins, minerals, and bioactive compounds. Some of the nutrients found in maitake mushrooms include:

  • Vitamins: Maitake mushrooms are a good source of vitamins B and C, which play vital roles in energy metabolism and immune function.
  • Minerals: They contain essential minerals such as potassium, calcium, and magnesium, which contribute to bone health and muscle function.
  • Polysaccharides: Maitake mushrooms are renowned for their beta-glucan content, a type of polysaccharide that has potential immune-boosting properties.
  • Antioxidants: Maitake mushrooms contain compounds like polyphenols and flavonoids, which act as antioxidants, protecting cells from oxidative stress and protecting against inflammation.

When maitake is used as a nutritional supplement, whole mushroom powder is most often the product of choice. Unlike maitake extract, which offers a concentrated dose of maitake’s bioactive compounds (like the polysaccharide D-Fraction), whole mushroom powder focuses on offering a hearty dose of all of the fiber, protein, vitamins, and minerals found in the raw maitake mushroom.

Potential Therapeutic Benefits

Research has suggested several potential health benefits associated with the consumption of maitake mushrooms:


Mushrooms have long been regarded as having immune-stimulating properties, and some research identifies Maitake as one of the most powerful functional mushrooms for boosting the immune system.

One study compared the immune boosting benefits of Shitake, Maitake, and a combination of the two. The research found that the combination extract was the most active in terms of stimulating the immune system defense response. On its own, maitake was second-most effective at stimulating immune reactions.

Anti-Cancer Potential

A 2012 study found that a Maitake extract was effective in killing human cancer cells and also increased the effectiveness of cancer-fighting proteins taken at the same time.

A 2013 study concluded that a Maitake extract may be able to prevent the growth and reproduction of cancerous cells, specifically that it may be useful for preventing or treating breast cancer.

Another 2013 animal study found that Maitake may help suppress tumor growth while boosting the immune response against the tumor. Mouse subjects were found to have a higher number of active immune cells fighting against tumor growth after taking regular Maitake doses.

More research is needed to fully understand how different Maitake preparations can be used to manage cancer in humans, but the overall immune-boosting potential is promising.

Cholesterol Support

A 2013 study found that Maitake extract could be beneficial for lowering high cholesterol, though the study involved animal subjects. Of course, the study also linked Maitake to other nutritional benefits, like an increase in fatty acids that convert to energy, which may help to keep the circulatory system healthy.

Diabetes (Lowering Blood Sugar)

A 2015 study investigated the potential benefits of Maitake mushrooms for rats with type 2 diabetes. Regularly consuming Maitake resulted in lower glucose levels. The authors believe that these results could translate to benefits in humans with diabetes, but more research is needed.

Antioxidant Properties

Maitake mushroom extract also exhibits potent antioxidant properties, which are vital in neutralizing harmful free radicals in the body. Free radicals are unstable molecules that can damage cells and contribute to oxidative stress, a process associated with various chronic health conditions. By scavenging these free radicals, the antioxidants in maitake extract help protect the body's cells from oxidative damage and maintain overall health.

Weight Management

Some research has indicated that maitake mushroom extract may play a role in weight management. The extract has been associated with increased metabolism and the promotion of satiety, which could contribute to better weight control. However, more studies are needed to fully understand the extent of its effects on weight management.

Possible Maitake Side Effects

While maitake mushrooms offer various potential benefits, it is crucial to be aware of their possible side effects and interactions, especially in certain individuals or when consumed in excessive amounts. 

Here are some of the known side effects:

Allergic Reactions

Like any other mushroom, some individuals may be allergic to maitake mushrooms. Allergic reactions can range from mild symptoms like skin rashes and itching to severe reactions like difficulty breathing, swelling of the face, tongue, or throat (anaphylaxis). If you experience any allergic symptoms after consuming maitake mushrooms, seek medical attention immediately.

This type of reaction is more common with whole mushroom products than extracts, but can occur with any type of maitake supplement. 

Digestive Issues

Some people may experience digestive discomfort after eating maitake mushrooms. This can include symptoms such as bloating, gas, stomach cramps, and diarrhea. These digestive issues are more likely to occur when maitake mushrooms are consumed raw or undercooked. 

This isn’t generally an issue for those consuming a high-quality maitake extract because most of the fiber is removed. However, whole mushroom products contain plenty of fiber and protein that may irritate digestion. 

Blood Sugar Interactions

While maitake mushrooms have been associated with potential blood sugar regulation benefits, they may interact with diabetes medications or other drugs that affect blood sugar levels. If you are on medication for diabetes or any other condition, consult your healthcare provider before adding maitake mushrooms to your diet.

You should also avoid taking maitake in combination with any medications used to manage blood sugar. 

Blood-Thinning Effects

Maitake mushrooms contain compounds that could potentially have blood-thinning effects. If you are already taking blood-thinning medications or have a bleeding disorder, consuming maitake mushrooms in large quantities might increase the risk of bleeding or interfere with your medication's effectiveness.

Immune System Modulation

While maitake mushrooms are known for their immune-boosting potential, this can be a double-edged sword for certain individuals. If you have an autoimmune condition or are on immunosuppressive medications, consuming large amounts of maitake mushrooms might overstimulate the immune system, potentially worsening your condition or interfering with your medication's efficacy.

Interactions with Medications

Maitake mushrooms may interact with various medications. It is essential to consult with your healthcare provider if you are considering maitake mushroom supplements while taking medications. Some medications that may interact with maitake mushroom supplements include:

  • Antidiabetic drugs
  • Antihypertensive drugs
  • Antidepressants
  • Anticoagulants
  • Antiplatelet drugs
  • Immunoregulatory drugs

Poor Quality and Contamination Risks

When choosing mushroom supplements, it is crucial to select reputable brands that adhere to strict quality standards. Poorly manufactured or contaminated supplements may pose risks such as bacterial or fungal contamination, heavy metal toxicity, or improper dosing. 

Look for products that have undergone third-party testing and carry certifications from reputable organizations to ensure quality and safety. In order to reap significant benefits, you should also look for formulas that contain a beta-glucan content of 20% or more. 

Heavy Metal Contamination

As with any wild-growing mushroom, there is a risk of heavy metal contamination. Maitake mushrooms can absorb heavy metals from the soil, particularly if they grow in polluted areas. Regular consumption of contaminated mushrooms could lead to heavy metal toxicity, which poses serious health risks.

How to Safely Consume Maitake Mushroom Supplements

Despite the potential side effects mentioned, maitake mushrooms can be safely consumed when proper precautions are taken. Here are some guidelines for safe consumption:

Purchase from Reputable Sources

When buying maitake mushrooms, ensure you purchase them from reputable sources that follow proper harvesting and quality control practices. Look for a high-quality supplement that’s lab tested to prove label accuracy. If you want a therapeutic supplement, choose a high-quality maitake extract made from 100% fruiting bodies. Avoid mycelium supplements and those that are double extracted, as they generally have a lower concentration of bioactive compounds.

To learn more, you may want to read:

Prepare Maitake Properly

To minimize the risk of digestive issues, always cook maitake mushrooms thoroughly. Cooking helps break down the mushroom's tough cell walls, making them more digestible and reducing the chances of adverse reactions.

If you use a maitake extract supplement, be sure to follow dosage guidelines. Overconsumption can increase the risk of maitake side effects, especially when using a concentrated product. 

Allergy Testing

If you have never consumed maitake mushrooms before, consider doing an allergy test before adding them to your diet. This can be done by consuming a small amount and monitoring for any adverse reactions.

Consult with a Healthcare Provider

If you have any underlying health conditions, are pregnant or breastfeeding, or are taking medications, it is crucial to consult with a qualified healthcare provider before incorporating maitake mushrooms into your diet or taking them as supplements.


Maitake mushrooms offer a range of potential health benefits and have been a staple in traditional medicine for centuries. However, like any other natural remedy or dietary supplement, they may have side effects and interactions that individuals need to be aware of. 

It's important to remember that maitake mushroom extract is not approved for medical use and is not designed to treat any condition. It can be an excellent addition to a healthy lifestyle and well-balanced diet, but it is always wise to consult with a healthcare professional before starting any new supplement regimen, particularly if you have existing health conditions or concerns.

Choosing a high-quality mushroom supplement is the first step to getting on your way with a new medicinal mushroom regimen. As it turns out, though, maitake may have synergistic benefits that make it a great match for other medicinal mushrooms and natural compounds. Our Lucid Mushroom+Nootropic stack displays this perfectly. 

The Lucid stack contains Alpha-GPC, L-Theanine, and L-Tyrosine, plus other nootropics (Ginkgo Biloba and BCAA’s) and four powerful medicinal mushrooms (Lion’s Mane, Cordyceps, Maitake, and Tremella).

When it’s all said and done, this nootropic + mushroom super blend adds up to offer these benefits and more:

If you’re looking for a nootropic stack to help bring you back into focus, check out the Lucid Starter Kit.

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