Nootropics for Anxiety Relief: What Works?

Nootropics for Anxiety Relief: What Works? - Lucid™

In a world where stress and anxiety have become pervasive, individuals are increasingly seeking alternative methods to manage their mental well-being. One such avenue gaining attention is the use of nootropics for anxiety relief.

Nootropics, often referred to as "smart drugs" or cognitive enhancers, are substances that claim to boost cognitive function and promote mental clarity. This article delves into the realm of nootropics, exploring their potential for anxiety relief and discussing which ones may offer effective solutions.

Key Takeaways

Some individuals are exploring nootropics as a complementary anxiety treatment due to their fewer side effects.

Certain nootropics show potential for anxiety relief, and each works through various mechanisms to alleviate stress and promote well-being.

Using nootropics for anxiety relief requires careful consideration. Starting with low doses, combining with lifestyle strategies, and consulting healthcare professionals can ensure safety and effectiveness.

Understanding Anxiety

Before delving into the potential benefits of nootropics, it's crucial to understand anxiety and its various forms. Anxiety is a common mental health condition characterized by excessive worry, fear, and nervousness.

While some level of anxiety is normal, chronic anxiety can significantly impact daily life and overall well-being. Traditional treatments for anxiety include therapy, medication, and lifestyle changes. However, some individuals are turning to nootropics as a complementary or alternative approach because they often produce fewer side effects and are not limited to those with a prescription.

What are Nootropics?

Nootropics, or "smart drugs," aim to enhance cognitive function by altering neurochemical balances in the brain. While their primary focus is on improving mental clarity, memory, and motivation, some nootropics may also exhibit properties beneficial for anxiety relief. Some are even well known for promoting a sense of calm or enhancing sleep

However, not all are likely anxiety remedies, and the impact varies based on their specific mechanisms of action. As researchers delve into the complex relationship behind nootropics for anxiety, the evolving field offers potential avenues for addressing cognitive function and mental well-being. 

Let’s take a look about what we currently know about the most promising nootropics for anxiety:

Promising Nootropics for Anxiety Relief

1. L-Theanine

L-Theanine, known for its calming effect, is a sought-after natural remedy for anxiety. It elevates serotonin, dopamine, and GABA levels, crucial in stress regulation. 

Particularly noteworthy is its impact on cortisol, the "stress hormone," bringing it to a healthy level. Studies affirm L-Theanine's dual role in reducing stress and improving sleep quality, making it a holistic solution for anxiety relief.

2. Ashwagandha

Ashwagandha, a revered adaptogenic herb rooted in Ayurvedic tradition, holds promising stress-relief potential. Fueled by bioactive withanolides in its roots, it intricately modulates the body's stress response, as evidenced by a 2012 study.

This versatile herb extends benefits beyond stress reduction, including support for fatigue and improved sleep. Ongoing research explores its broad applications. However, caution is essential due to potential hormone-related side effects, especially in men. Consulting a healthcare professional before incorporating ashwagandha ensures a personalized and informed approach.

In summary, ashwagandha stands as a holistic stress solution, blending tradition with modern research for comprehensive well-being.

3. Rhodiola Rosea:

Rhodiola Rosea, an adaptogenic gem, extends its benefits to anxiety relief through neurotransmitter balance. Research indicates its potential as an antidepressant, aligning neurotransmitters in the brain.

In a 12-week study comparing it with sertraline, both demonstrated a reduction in depressive symptoms. While sertraline had a stronger impact, Rhodiola rosea stood out for its fewer side effects and better tolerance. Beyond anxiety, its adaptogenic nature offers a natural and well-tolerated mood-boosting alternative, promising emotional balance and mental well-being.

4. Ginkgo Biloba:

Ginkgo Biloba, an ancient herbal remedy originating in China, is now recognized for its adaptogenic prowess. Research reveals its efficacy in managing acute stress, promoting neurogenesis to reduce long-term stress impact, and relieving anxiety associated with an imbalanced stress response.

In a 2007 study, participants taking Ginkgo reported higher anxiety relief than the placebo group, emphasizing its potential in contemporary anxiety management. This botanical treasure seamlessly blends traditional wisdom with scientific insights for holistic well-being.

5. Lion's Mane

Lion's Mane offers a rejuvenating mental spa day for your brain, celebrated for its cognitive benefits and potential anxiety relief. While not all studies directly address anxiety, this mushroom is linked to increased production of brain-derived neurotrophic factor (BDNF), fostering the creation of new neural pathways and enhancing mental well-being.

6. Cordyceps

Cordyceps serves as a natural energy booster and mood enhancer, elevating oxygen uptake for improved energy levels and reduced fatigue--among many other potential benefits. Studies hint at its potential to lower anxiety, with added benefits of enhancing physical stamina and vitality, indirectly contributing to anxiety reduction. Harness the natural vitality of Cordyceps for a balanced and energized well-being.

7. Reishi

Reishi, revered as the "Mushroom of Immortality," boasts unparalleled adaptogenic prowess. This fungal champion aids the body in adapting to stressors and is associated with reduced anxiety and enhanced sleep quality.

Scientific studies indicate that Reishi holds the potential to promote relaxation and emotional well-being, with some suggesting efficacy comparable to prescription diazepam. Embrace the holistic benefits of Reishi as it takes you on a journey toward tranquility and well-being.

8. Maitake

Maitake, a noteworthy functional mushroom with potential anxiety-relief properties, is rich in compounds that may regulate stress hormones and induce a sense of calm. While research on its anxiety effects is limited, there's evidence suggesting brain-boosting and antidepressant effects, possibly linked to its interactions with AMPA receptors. It contains betaglucans, compounds that have also been linked to antidepressant effects.

Additionally, maitake, when combined with ashwagandha, demonstrated a significant decrease in cortisol production in animal models, hinting at adaptogenic potential.

Incorporating maitake into your routine, whether through supplements or culinary endeavors, could be transformative in your anxiety relief journey. However, individual responses vary, emphasizing the importance of consulting with a healthcare professional before introducing new supplements.

9. Holy Basil Leaf

Holy Basil Leaf, also known as Tulsi, stands as a potent adaptogenic herb widely incorporated in stress-supporting formulations. Emerging evidence points to its potential in enhancing cognition and reducing salivary cortisol levels. Additionally, this herb is believed to address stress-related concerns, including elevated blood pressure and blood sugar levels.

A noteworthy 2012 double-blind, placebo-controlled trial highlighted the efficacy of holy basil. Subjects in the study reported a remarkable 39% improvement in self-reported stress symptoms over a six-week period, underscoring its significance in stress management.

How to Use Nootropics for Anxiety

When considering the use of nootropics for anxiety relief, a strategic approach is essential to maximize benefits while minimizing potential risks. Here's a guide on how to use nootropics effectively:

1. Research and Consultation:

  • Prioritize thorough research on specific nootropics known for anxiety relief.

  • Consult with a healthcare professional to ensure compatibility with your individual health profile.

2. Start with Low Doses:

  • Begin with lower doses to gauge individual responses and minimize the risk of adverse effects.

  • Gradually increase doses if needed, under professional guidance.

3. Identify Mechanisms of Action:

  • Understand the mechanisms of action for selected nootropics, focusing on those with anxiety-reducing properties.

  • Match the chosen nootropic's mechanism with your specific anxiety symptoms for targeted relief.

4. Combine with Lifestyle Strategies:

  • Integrate nootropics into a holistic approach, combining them with healthy lifestyle choices. Look for nootropic coffee, tea, or other convenient supplements for integrating nootropics into your current routine. 

  • Incorporate stress management techniques, exercise, and a balanced diet for comprehensive well-being.

5. Monitor Effects:

  • Regularly assess the impact of nootropics on anxiety symptoms.

  • Pay attention to changes in cognitive function, mood, and overall mental well-being.

6. Rotate Nootropics if Needed:

  • Consider rotating different nootropics to prevent tolerance and maintain effectiveness.

  • Observe how different substances complement each other for a personalized approach.

7. Be Mindful of Side Effects:

  • Stay vigilant for any potential side effects and promptly address concerns with a healthcare professional.

  • If adverse effects are experienced, adjust dosage or consider alternative nootropics.

8. Regular Check-ins with Healthcare Professionals:

  • Schedule regular check-ins with healthcare professionals to discuss the ongoing use of nootropics.

  • Adjust the approach based on professional advice and any changes in health status.

Remember, individual responses to nootropics can vary, and what works for one person may not be suitable for another. It's crucial to approach their use with caution, mindfulness, and professional guidance for a tailored and effective strategy in managing anxiety.


While nootropics show promise as potential aids in anxiety relief, it's essential to approach their use with caution. Individual responses to these substances can vary, and more research is needed to establish their efficacy and safety.

Before incorporating any nootropic into your routine, it's advisable to consult with a healthcare professional. Additionally, combining nootropics with traditional anxiety treatments and adopting a holistic approach to mental well-being may yield the most effective results.

 As the landscape of mental health solutions continues to evolve, exploring nootropics for anxiety relief opens up new possibilities for those seeking alternative paths to a calmer, more balanced state of mind.

Lucid beverages contain a blend of brain-boosting nootropics + powerful mushrooms designed to unlock your brain's full potential so you can zone in on what's important. 

Ready to become lucid?  Check out our starter kit. 


  1. “Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial”

  2. “Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974”

  3. “Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial”

  4. “Anti-stress Effects of Ginkgo biloba and Panax ginseng: a Comparative Study”

  5. “Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial”

  6. “Active compound in Lion’s Mane mushroom improves nerve growth and memory”

  7. “Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation”

  8. “Griflola frondosa (GF) produces significant antidepressant effects involving AMPA receptor activation in mice”

  9. “Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future”

  10. “Immune enhancing effects of WB365, a novel combination of Ashwagandha (Withania somnifera) and Maitake (Grifola frondosa) extracts”

  11. “Tulsi - Ocimum sanctum: A herb for all reasons”

  12. “Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study”

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