creatine and adhd cover photo

Exploring the Connection Between Creatine and ADHD: What the Science Says

Written by: Kat Austin

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Time to read 9 min

ADHD, or Attention Deficit Hyperactivity Disorder, affects countless individuals, presenting challenges in attention, hyperactivity, and impulsivity. While traditional treatments strive to alleviate these symptoms, there's a buzz around a potential game-changer: creatine supplementation for brain benefits


Recent studies are hinting at a connection between creatine and ADHD symptoms, sparking curiosity about its role in managing this condition. So, what are creatine ADHD benefits?


If the research holds true, creatine may help ADHD by enhancing brain energy levels, which could lead to improved focus and cognitive function. In fact, people with ADHD are known to have low brain levels of creatine, and supplementing may help support overall cognitive balance.


Let's dive in and uncover the details behind using creatine for ADHD:

Key Takeaways

  • Emerging research hints that creatine supplementation might help manage ADHD symptoms by improving cognitive performance.
  • Creatine may boost working memory, intelligence, and attention span, showing promise as a nootropic.
  • Creatine is generally safe for healthy adults, but consult a healthcare professional before use, especially if taking other medications or having health conditions.

What is ADHD?

Attention Deficit Hyperactivity Disorder (ADHD) affects individuals of all ages, profoundly impacting daily functioning, cognition, relationships, and more. According to the Centers for Disease Control and Prevention, it's a prevalent neurodevelopmental disorder, affecting approximately 8.8% of children and 2.5% of adults.


Symptoms such as difficulties in maintaining attention, episodes of hyperactivity, and impulsive behavior can significantly disrupt daily life. Additionally, individuals with ADHD may experience less common symptoms like problems with eye contact, fatigue, or hypermobility.


While current treatments, including stimulant and non-stimulant medications, alongside behavioral therapies and lifestyle interventions, aim to manage symptoms, they often carry risks of unwanted side effects. This underscores the pressing need for alternative approaches to comprehensively address ADHD symptoms.


So, where does creatine fit into the ADHD equation? Let's explore further.

Creatine and ADHD: Basics and Benefits

Creatine, a naturally occurring compound primarily found in muscle cells, plays a crucial role in energy metabolism. Studies have highlighted its potential cognitive benefits, with creatine supplementation being linked to improved cognitive performance.


In fact, creatine has been linked to powerful nootropic effects, and it’s thought to help boost several areas of cognition, including working memory and cognitive endurance.


Low creatine levels are associated with neurological conditions like ADHD. Creatine deficiency may affect individuals with specific genetic defects in creatine biosynthesis or transport, resulting in various intellectual disabilities, developmental delays, ADHD, ASD, and seizures.


However, the evidence regarding its impact on ADHD is still limited. While many people have used creatine to manage ADHD symptoms with positive results, creatine is only one part of a well-rounded cognition-supporting regimen. Many people stack creatine with certain natural stimulants and other ADHD-supporting supplements for enhanced benefits. 


Let’s take a look at the research surrounding creatine and ADHD:

The Science Behind Creatine and ADHD

Creatine may hold promise in influencing ADHD symptoms, but the evidence is overall inconclusive.


Some studies propose that creatine supplementation could positively affect cognitive performance by bolstering brain creatine levels, potentially offering relief for ADHD symptoms.


However, contrasting findings from other studies (2007, 2017) indicate no substantial alterations in cognitive function or brain creatine content among ADHD patients following creatine supplementation.


Although evidence regarding creatine's benefit for ADHD has been mostly inconclusive, other evidence exists to support creatine's use as a nootropic for general cognition enhancing benefits. For instance:


  • Creatine May Boost Working Memory and Intelligence

    • study at the University of Sydney found that creatine supplementation improved working memory and intelligence in young adult vegetarians, who typically have lower creatine levels due to diet.

    • Participants took 5 grams of creatine daily for 6 weeks in a double-blind, placebo-controlled trial.

  • It May Increase IQ and Attention Span

    • Research conducted by the University of Sunderland involved giving 5 grams of creatine daily to healthy non-vegetarians for 2 weeks.

    • The creatine group showed improvements in memory, attention, and IQ tests compared to the placebo group.


  • Creatine May Repair Brain Cells and Provide Neuroprotective Effects

    • Limited evidence suggests creatine could offer neuroprotective effects against diseases like Parkinson's and Alzheimer's.

    • Creatine's role in supporting brain energy metabolism makes it a promising candidate for therapies targeting cell repair and replacement in neurological diseases.

Is Using Creatine for ADHD Safe?

When considering the safety of using creatine for ADHD, it's crucial to weigh the potential benefits against the risks. 


While creatine may provide relief for some ADHD symptoms, there are some mild concerns regarding its long-term effects and safety. However, creatine is not known to be habit forming, so it may be a safer alternative to certain ADHD medications. 

Potential Side Effects of Creatine Supplementation

Potential side effects of creatine supplementation include gastrointestinal issues like nausea, diarrhea, and stomach cramps. Additionally, there's a risk of dehydration, especially if adequate water intake isn't maintained while using creatine.


It's also essential to be cautious about interactions with other medications or supplements, as creatine may interact with certain drugs, such as diuretics or nonsteroidal anti-inflammatory drugs (NSAIDs).

Can You Take Creatine with Adderall?

Many people who suffer from ADHD or related conditions may take a stimulant medication such as Adderall to manage symptoms. Thankfully, you may still be able to try creatine for ADHD while taking Adderall or similar medications.


There have been no adverse interactions found between Adderall and creatine. Of course, you should still talk to your doctor when including new supplements in your wellness regimen.

Creatine Dosage for ADHD

When using creatine for ADHD, a common dosage recommendation is 3 to 5 grams per day. This amount is generally considered safe and effective for supporting brain function and energy metabolism, which may contribute to the creatine ADHD benefits, such as improved focus and cognitive function.


However, the optimal dosage can vary depending on individual needs and responses. It's important to consult with a healthcare provider before starting creatine and ADHD supplementation to determine the best approach for your specific situation. This ensures that you can safely maximize the potential benefits of creatine for ADHD management.


When to Take Creatine for ADHD

Creatine may be best taken in the morning if you hope to reap nootropic effects. However, some people have seen benefits from splitting their creatine dose into two portions, taking one in the morning and one in the early afternoon.


Read "When To Take Creatine for Brain Health, Muscle Recovery & More" to learn more.

Who Shouldn’t Take Creatine?

Although creatine is thought to be safe for the liver in healthy adults, those with liver or kidney problems shouldn’t take creatine. Furthermore, creatine should not be given to people who are pregnant or children without a doctor’s guidance.


Some evidence suggests that creatine can impact blood sugar and blood pressure, so talk to your doctor if you have concerns. 


Individuals should consult with a healthcare professional about the safety of creatine supplementation when combined with their current health regimen, particularly if they have underlying medical conditions or are taking medications. 


Monitoring for any adverse reactions and adjusting dosage as needed is essential to ensure safety while using creatine for ADHD management.

Other Creatine Benefits

While creatine may benefit individuals with ADHD by boosting brain health, it also provides a range of other benefits. Creatine is best known for improving physical performance, but its benefits extend to other areas like cognitive function and muscle recovery.

Increased Muscle Recovery and Performance

Creatine helps reduce muscle inflammation and boosts protein synthesis,  speeding up recovery after intense workouts. This allows athletes to train more frequently and consistently, enhancing long-term performance.


Studies show creatine improves strength and endurance, making it valuable for both strength training and high-intensity sports. This is one reason that creatine may be used by runners or other high-endurance athletes.

Enhanced Glycogen Storage

Creatine increases glycogen storage in muscles by promoting insulin secretion, which helps muscles absorb glucose. This boost in glycogen enhances exercise endurance, especially during moderate- to high-intensity activities.


Athletes, such as runners, can exercise longer and at a higher intensity, delaying fatigue and improving overall performance. As a bonus, this may also give creatine certain benefits for managing blood sugar.

Strength Gains and Resistance Training

For those incorporating weight training into their routine, creatine has been shown to improve strength and hypertrophy (muscle growth). 


Creatine provides more energy to muscles, allowing for more intense training sessions and better performance in resistance exercises. This leads to improved muscle endurance and resilience, further enhancing overall athletic performance.

Neuroprotective Effects

There is emerging evidence that creatine could offer neuroprotective benefits, particularly for individuals at risk of neurological diseases and dementia, like Parkinson's and Alzheimer's. 


Creatine supports cellular energy metabolism in the brain, potentially aiding in the repair of brain cells and protecting against neurodegeneration. While further research is needed, creatine's potential in this area is promising.

Conclusion

So, can you take creatine for your ADHD? Well, while early research hints at a potential link between creatine and cognitive function, we're not quite there yet. We need more studies to really understand how creatine fits into managing ADHD.


Still, creatine is safe for healthy adults and may provide nootropic benefits that help to improve focus, endurance, memory, and more. It may be a suitable option for anyone looking for a tried and true nootropic supplement to help ease the symptoms of ADHD.


Pair it with other nootropics for ADHD to create a personalized stack that supports overall cognitive function and gives you the boost you need.




Lucid beverages contain a blend of brain-boosting nootropics + powerful mushrooms designed to unlock your brain's full potential so you can zone in on what's important. 


Ready to become lucid?  Check out our starter kit. 

FAQ - Creatine ADHD

Does creatine affect ADHD?

Creatine’s effects on ADHD are not well-studied, but some research suggests that creatine may support brain energy metabolism, which could potentially benefit cognitive functions. However, more research is needed to understand its specific impact on ADHD.

Does creatine help improve focus?

Creatine has been shown to enhance cognitive performance in some studies, particularly in tasks that require short-term memory and quick thinking. While it may help improve focus, its effects can vary from person to person.

Does creatine affect Adderall?

There is limited research on the interaction between creatine and Adderall. Creatine does not appear to directly affect Adderall’s effectiveness, but it's essential to consult with a healthcare provider before combining supplements with prescription medications.

Does creatine affect dopamine levels?

Creatine may influence brain energy metabolism, but there is no clear evidence that it directly affects dopamine levels. Its impact on neurotransmitters like dopamine is not well understood and may require further research.

Can creatine mess with your mood?

Some users report mood changes when taking creatine, though these are generally mild and infrequent. Creatine is more commonly associated with physical rather than psychological effects, but individual responses can vary.

Can creatine cause brain fog?

Brain fog is not a common side effect of creatine, but everyone reacts differently to supplements. If you experience brain fog while taking creatine, it may be worth discussing with a healthcare provider to determine the cause.

Resources

  1. “Attention Deficit Hyperactivity Disorder (ADHD)”  https://www.cdc.gov/nchs/fastats/adhd.htm

  2. “What is ADHD?”  https://www.psychiatry.org/patients-families/adhd/what-is-adhd

  3. “Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study”  https://pubmed.ncbi.nlm.nih.gov/28079396/

  4. “Evidence of brain dysfunction in attention deficit-hyperactivity disorder: a controlled study with proton magnetic resonance spectroscopy”  https://pubmed.ncbi.nlm.nih.gov/17707309/

  5. “Effects of methylphenidate treatment on the cerebellum in adult attention-deficit hyperactivity disorder: a magnetic resonance spectroscopy study”  https://pubmed.ncbi.nlm.nih.gov/28165547/

  6. “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial”  https://pubmed.ncbi.nlm.nih.gov/14561278/

  7. “Cognitive effects of creatine ethyl ester supplementation”  https://pubmed.ncbi.nlm.nih.gov/19773644/

  8. “Anti-Inflammatory and Anti-Catabolic Effects of Creatine Supplementation: A Brief Review”  https://pmc.ncbi.nlm.nih.gov/articles/PMC8839648/

  9. “Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations”  https://pmc.ncbi.nlm.nih.gov/articles/PMC8228369/

  10. “A review of creatine supplementation in age-related diseases: more than a supplement for athletes” https://pmc.ncbi.nlm.nih.gov/articles/PMC4304302/#:~:text=New+studies+indicate+that+creatine,%2C+Alzheimer's+disease%2C+and+stroke .

  11. “Potential of Creatine in Glucose Management and Diabetes” https://pmc.ncbi.nlm.nih.gov/articles/PMC7915263/#:~:text=Creatine+itself+may+stimulate+insulin,glucose+uptake+and+insulin+sensitivity .

  12. “A review of creatine supplementation in age-related diseases: more than a supplement for athletes” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304302/#:~:text=New+studies+indicate+that+creatine,%2C+Alzheimer%27s+disease%2C+and+stroke .

Kat Austin Author Profile Photo

Kat Austin

Kat is a Senior Writer at Lucid with over a decade of experience crafting engaging health and lifestyle content. When she's not sharing health hacks, you can find her foraging nearby her own backyard or backpacking somewhere bobcats roam.