Creatine and Kratom: A Deep Dive into Their Effects When Combined - Lucid™

Creatine and Kratom: A Deep Dive into Their Effects When Combined

Written by: Kat Austin



Time to read 8 min

Creatine and kratom are two popular supplement choices each with unique benefits. Creatine is loved by athletes for its ability to boost muscle mass and improve exercise performance. Kratom is a traditional herb known for relieving pain and enhancing mood.

With supplement stacking on the rise, many people are combining creatine and kratom to reap enhanced benefits. Together, these two can enhance workout performance, speed up recovery, and manage pain effectively.

Curious about the connection between the two? Here’s everything you need to know about the benefits, risks, and science behind this combination.

Key Takeaways

Combining creatine and kratom may enhance workout performance, recovery, and pain management.

While the combination shows promise, it is important to be cautious of potential side effects such as dehydration, digestive issues, and central nervous system disturbances.

While many users report positive outcomes from combining kratom and creatine, you should always consult your healthcare professionals first.

What is Creatine?

Creatine is a naturally occurring compound found in small amounts in certain foods and synthesized by the body. It is mostly stored in the muscles, where it plays a critical role in the production of adenosine triphosphate (ATP), the primary energy supplier within the cells.

Because it can enhance muscular energy, especially during quick burst activities, creatine is a staple supplement for those looking to improve strength, increase muscle mass, and enhance overall athletic performance.

How Creatine Works

Creatine plays a vital role in energy production, particularly during intense, short-duration exercises like weightlifting or sprinting. 

When muscles rapidly consume ATP (adenosine triphosphate), the primary energy source, creatine steps in to regenerate ATP molecules by donating a phosphate group to ADP (adenosine diphosphate), ensuring a continuous energy supply for muscle contraction.

This process increases phosphocreatine levels in muscle cells, prolonging ATP availability and enabling muscles to sustain high-intensity efforts for longer periods. Ultimately, creatine supplementation enhances performance and strength, and delays fatigue during explosive activities, making it a valuable tool for athletes and fitness enthusiasts.


  • Increased muscle mass and strength.

  • Enhanced recovery and reduced muscle damage.

  • Improved performance in high-intensity activities.

What is Kratom?

Kratom , scientifically known as Mitragyna speciosa, grows naturally in Southeast Asia. Its leaves pack a punch with psychoactive compounds known to produce opioid-like effects. In the West, it's gained fame for its pain relief, mood lift, and energy boost.

How Kratom Works

The active compounds in kratom, primarily mitragynine and 7-hydroxymitragynine, interact with the body’s opioid receptors, producing effects similar to both stimulants and opioids. At lower doses, kratom acts as a stimulant, increasing alertness and energy. At higher doses, it exhibits sedative and pain-relieving properties.


  • Effective pain relief.

  • Enhanced mood and reduced anxiety.

  • Increased energy and focus at lower doses.

Combining Creatine and Kratom

Combining creatine and kratom has gained traction among users. Creatine is known for boosting muscle strength and exercise performance. Kratom, on the other hand, is valued for its pain relief and mood enhancement. 

People combine these supplements for a variety of reasons, seeking to maximize their energy, endurance, mood, and pain management during physical activities.

Potential Benefits

When combined, creatine and kratom might offer complementary benefits that enhance both performance and recovery. Creatine’s ability to boost energy and muscle performance could synergize with kratom’s pain-relieving and mood-enhancing effects, potentially leading to:

  • Improved exercise performance and endurance.

  • Enhanced muscle recovery and pain management post-workout.

  • Better mood and motivation for training sessions.

Possible Interactions

While the combination of creatine and kratom is relatively unexplored scientifically, it is important to consider how these substances might interact.

Creatine primarily affects muscle energy metabolism, while kratom influences the central nervous system. This combination could potentially amplify the overall energy boost and pain relief experienced, but it might also increase the risk of side effects, including:

  • dehydration

  • digestive issues

  • central nervous system disturbances

  • sleep disturbances

Creatine + Katom: Scientific Research and Evidence

While there is substantial research on creatine and kratom individually, studies on their combined use are scarce.

Creatine has been extensively studied and is well-documented for its benefits in sports and exercise contexts. Furthermore, creatine may have nootropic benefits that help improve cognitive function. Some other research-backed benefits of creatine include:

  • Enhanced muscle strength and power during high-intensity activities (2021 )

  • Increased muscle mass and hypertrophy ( 2022 )

  • Improved exercise performance, especially in short-duration, high-intensity activities like weightlifting and sprinting ( 2012 )

  • Accelerated post-exercise recovery, reducing muscle soreness and fatigue ( 2024 )

  • Enhanced brain function and cognitive performance, particularly in tasks requiring short-term memory and decision-making ( 2023 )

  • Potential protective effects against neurological diseases like Parkinson's and Alzheimer's, although further research is needed to confirm these benefits ( 2014 )

  • Improved hydration status due to creatine's ability to increase water retention in muscle cells, which may benefit overall athletic performance and exercise endurance ( 2012 )

Kratom research is growing, particularly regarding its potential as a pain management alternative and its psychoactive effects. Some research-backed benefits may include:

  • Potential pain relief. Studies have shown that kratom's active compounds, mitragynine and 7-hydroxymitragynine, interact with opioid receptors in the brain to provide significant pain relief, similar to traditional opioids ( 2016 )

  • Improved mood and reduction of anxiety. Research indicates that kratom can act as a mood enhancer and anxiolytic, helping to reduce symptoms of depression and anxiety ( 2015 )

  • Increased energy and alertness. At lower doses, kratom has stimulant-like effects, increasing energy, alertness, and sociability ( 2018 )

  • Enhanced focus and cognitive performance. Some users report improved focus and cognitive function, although more research is needed to fully understand these effects ( 2016 )

  • Possible neuroprotective effects. Preliminary studies suggest kratom may have neuroprotective properties, but further research is required to confirm these potential benefits ( 2020 )

    However, no comprehensive studies have examined the combined effects of creatine and kratom, highlighting a significant gap in the scientific literature. Still, some anecdotal reports may help us understand their potential.

Anecdotal Evidence

Some users have reported positive experiences combining creatine and kratom, citing enhanced workout performance and improved recovery. Others suggest that the greatest benefit is energy enhancement and improved focus. Many claim to use the two daily with zero negative side effects , while others stress the importance of increasing your water intake to avoid dehydration.

How to Use Creatine and Kratom Safely

Before you combine kratom and creatine, here’s what you should consider:

Dosage and Administration

Proper dosage is crucial when using any supplement, and this is especially true when combining creatine and kratom.

The recommended dosage for creatine is typically 3-5 grams per day, while kratom dosage can vary widely depending on the desired effect. Beginners might start with 1-2 grams of kratom for stimulating effects, gradually increasing as needed.

When combining, it is essential to start with lower doses of each to monitor for any adverse reactions.

Potential Side Effects and Risks

Combining creatine and kratom could amplify certain side effects:

  • Dehydration: Both substances can increase the risk of dehydration, so maintaining adequate hydration is crucial.

  • Digestive Issues: Both supplements can cause gastrointestinal discomfort; combining them might exacerbate these effects.

  • Central Nervous System Impact: Kratom’s interaction with opioid receptors and creatine’s impact on energy metabolism could potentially lead to unpredictable effects on the central nervous system.

Legality and Regulations

The legal status of kratom varies by region, with some areas banning its use due to safety concerns and potential for abuse. Creatine, on the other hand, is widely available and legal in most countries. Users must be aware of local regulations and ensure they are compliant with the law when using these supplements.

Who Might Benefit from This Combination?

Individuals who might benefit from combining creatine and kratom include:

  • Athletes looking for enhanced performance and recovery.

  • Individuals with chronic pain seeking non-prescription pain relief.

  • Those needing a mood and energy boost for demanding physical activities.

Who Should Avoid Creatine and Kratom?

Certain groups should avoid combining creatine and kratom:

  • Pregnant or breastfeeding women.

  • Individuals with pre-existing kidney or liver conditions. Despite popular belief, creatine is safe for the liver in healthy adults.

  • Those with a history of substance abuse or addiction.

Consulting with a healthcare provider before starting any new supplement regimen is crucial to ensure safety and appropriateness based on individual health conditions.


Combining creatine and kratom presents an intriguing possibility for those looking to enhance their physical performance and manage pain. While anecdotal evidence suggests potential benefits, the lack of comprehensive scientific research means users must approach this combination with caution. 

Understanding the individual effects, potential interactions, and safety considerations is essential. Consulting healthcare professionals and staying informed about ongoing research can help users make safe and effective choices.

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FAQ Section: Creatine and Kratom

1. What should you not mix with creatine?

Avoid mixing creatine with caffeine and alcohol, as they can reduce its effectiveness and cause dehydration.

2. Does creatine react with any drugs?

Creatine generally does not react with most drugs but consult your healthcare provider if you are on medications that affect the kidneys.

3. What can you stack creatine with?

Creatine is commonly stacked with beta-alanine, BCAAs, and protein supplements to enhance muscle endurance, recovery, and growth.

4. Can you take creatine with other supplements?

Yes, creatine can be taken with protein powders, pre-workout supplements, and amino acids. Be mindful of dosages to avoid negative interactions.

5. What is kratom, and what are its uses?

Kratom is a tropical tree used for pain relief, energy boosting, and managing opioid withdrawal symptoms. It has potential risks, including dependency and withdrawal.

6. Can you mix creatine and kratom?

The safety of mixing creatine and kratom is unclear and not well-researched. Consult a healthcare provider before combining them.


  1. “Creatine Monohydrate: Benefits, Side Effects, Dosages & FAQ”

  2. “Kratom: Uses, Effects, Hazards & Abuse Potential”

  3. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials - PubMed

  4. The pharmacology and toxicology of kratom: from traditional herb to drug of abuse - PubMed

  5. Combining creatine with caffeine and bitter orange extract - National Institutes of Health (NIH)